The thyroid gland uses iodine in producing thyroxine (T4) and triiodothyronine (T3). By using iodine tracers we can see where the iodine is going in the body. A normally functioning thyroid gland will have a high concentration of the labeled iodine, since it will take it up to produce new T4 and T3. A nonfunctioning thyroid will not. (That's my understanding of the process anyway, but keep in mind I'm a pharmacist, so I'm not as well-versed as physicians in the diagnosis of illness.)
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